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On the other hand, it is not advised to use these drugs for a long-term since the protein expressions of CYP isozymes involved in steroidogenesis as well as the numbers of spermatocytes in testes were decreased.

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We find strong associations of the melanin biosynthesis gene TYRP1 , ferroptosis related enzyme GPX4 and mitochondrial anion channel ( VDAC1 ) with reduced melanoma-specific survival in TCGA data of cutaneous melanoma