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npj Aging 11 , 41 (2025)

doi: 10.1126/science.505013 157 JaureguiC.Blanco-LuquinI.MacasM.RoldanM.CaballeroC.PagolaI.et al

It binds a receptor in the pituitary and brain and tells the body to release a short burst of its own growth hormone

As such, circadian-informed precision geromedicine, where both the timing and the nature of interventions are tailored to the aging clock, emerges as a foundational strategy not only to enhance therapeutic efficacy and reduce toxicity, but also to recalibrate biological time itself, preserving physiological harmony across the aging trajectory

When FOXO activity decreases in activated NSCs, metabolism shift toward lipogenesis and oxidative phosphorylation (OXPHOS), leading to ROS signalling that promotes neuronal differentiation (Ludikhuize and Rodriguez Colman, 2021)