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Such a negative feedback loop offers a resolution for overcoming ferroptosis inducer resistance
Additionally, ERO1A influences immunogenic cell death in tumor cells by regulating the balance between IRE1 and PERK signaling, attenuating the therapeutic efficacy of PD-1 blockade [91]
doi: 10.1177/1352458515601513
et al (2014) J Biol Chem
Impaired serine metabolism reduces H3K27 trimethylation on histones, which upregulates IGF1 and activates the p38JAK/STAT1 pathway to drive M1 polarization while inhibiting M2 polarization (115)
