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Key points No currently available oral or topical therapy is effective as a monotherapy, but some have shown encouraging results as a part of combination therapy
Synthesis and in Evaluation of a Phosphonate Prodrug: Bis(pivaloyloxymethyl) 9-(2- Phosphonylmethoxyethyl)adenine

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By blocking adenosine A1 receptors, caffeine causes dilation of the feeding arterioles in the glomeruli, thereby increasing filtration pressure
