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It was designed at Monash University in Australia to isolate growth hormone's fat-metabolizing activity while stripping out everything else the growth-promoting effects, the IGF-1 elevation, the insulin antagonism, the fluid retention

Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)

This is both its greatest advantage and a source of concern, because removing too much fat tissue could have consequences for metabolic homeostasis, hormone production, and energy storage capacity

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