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D.FazoJ.et al (2012)

The malondialdehyde (MDA) level was significantly increased and the superoxide dismutase (SOD) and glutathione (GSH) levels were significantly decreased after high glucose treatment, with these results being reversed by curcumin

Taken together, anti-GAD65Ab elicit marked imbalance in neurotransmitters

Methods for identification of the DMF targetome As mentioned, the therapeutic efficacy of DMF was mainly attributed to KEAP1 succination, which resulted in stabilization of NRF2 leading to activation of the antioxidant response element (ARE)