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Gastric mucosa performs limited first-pass metabolism before ethanol reaches portal circulation, reducing bioavailability slightly before systemic distribution begins
[DOI] [PubMed] [Google Scholar] 135.Xin Y., Ben P., Wang Q., Zhu Y., Yin Z., Luo L
Oxidative stress also contributes to thyrocyte apoptosis, with reduced antioxidant defenses (e.g., glutathione peroxidase and superoxide dismutase activity) often observed in patients with autoimmune thyroiditis
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Therefore, we can target SAM by reducing its production upstream and inhibiting its methyltransfer downstream
