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The most common reason is chemical compatibility
In response to previous comments in the CY 2022 HH PPS rule urging CMS to seek technical expert panel (TEP) recommendations to better inform the development of the SFP, a TEP was convened to gain input from key stakeholders on various aspects of the proposed SFP

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However, once the benzimidazole is detached from cobalt by quaternization with methyl iodide, it is replaced by H 2 O or hydroxyl ions
