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To address this, we chose primary hepatocytes cultured in a sandwich configuration as this is the preferred method for in vitro drug disposition and hepatotoxicity studies (44)

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these observations corroborate the notion that specific subtle constraints must exist whereby a particular G6PD variant has a distinctly severe clinical expression but remains compatible with life

Third, the ACSL4-LPCAT3 lipid remodeling pathway is critical for sensitizing mesenchymal-like drug-resistant cancer cells

This allows the body to safely clear toxic homocysteine while maintaining a continuous, sustainable supply of cysteine for ongoing antioxidant defense