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Biochim Et Biophys Acta (BBA)-Mol Cell Res 1867:118664

GzmB, a caspase-like serine protease, triggers apoptosis of virus-infected cells or tumor cells by activating caspases-3 and -8 ( It has been established that Sb9 can protect tumor cells from GzmB mediated destruction, whether GzmB originates from cytotoxic lymphocytes or is produced endogenously ( regs ] and myeloid-derived suppressor cells [MDSCs]) ( Its worth noting that apart from its role in regulating GzmB, human Sb9 can also influence cytokine production by modulating inflammatory caspase-1, and to a lesser extent caspase-4 and caspase-8, but not caspase-3 ( asso (association rate constant) value and lack of data on Sb9 RCL cleavage or caspase-Sb9 complex formation, the physiologically significant interaction between Sb9 and these caspases is limited and unpersuasive ( Besides as a protease inhibitor, several studies have indicated murine Sb9 functions in the regulation of antigen presentation and the cell-associated antigen cross-presentation by CD8 + splenic dendritic cells, independently of GzmB ( Considering the vital role of Sb9 in numerous physiological functions, gaining a deeper insight into its regulation, encompassing both intracellular factors and extracellular environment, could offer profound implications for clinical practice

Theracurmin showed higher absorption efficiency than the comparators

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