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it also slows down the process of ferroptosis in cardiomyocytes during ischemia period to alleviate MI and HF (Zozina et al., 2018)

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Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling, K

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The study used a single high dose and did not evaluate symptoms, disease outcomes or long-term use

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We believe that significant efforts should be put into investigating in greater detail the pathways shared by eryptosis and erythronecroptosis, like caspase-8, ROS signaling, Fas/FasL signaling, to collect more evidence on the interplay between these erythrocyte-specific RCDs

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