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The role of insulin-like growth factor 1 in ALS cell and mouse models: A mitochondrial protector

The Toll-like receptor 4 (TLR4)/PI3K/Akt pathway converges with ER stress responses to amplify AT inflammation (107)

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Despite its potential, the clinical limitations of D-penicillamine primarily stem from its nonspecific metal chelating properties (resulting in nephrotoxicity and hepatotoxicity), immunogenicity (leading to Goodpastures syndrome-like manifestations or systemic lupus erythematosus (SLE)-like symptoms in approximately 5%10% of patients), and the cumulative toxicity of its metabolites

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