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In humans, data from SARS and Middle East respiratory syndrome also showed that neurological injury in humans is rare, strongly suggesting that, normally, the BBB provides robust neuroprotection from viral CNS invasion in most patients 30

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Meanwhile, in another clinical trial (NCT02414295), congenital male oligozoospermia or azoospermia caused by Klinefelter syndrome was also investigated through the injection of BM-MSCs into the testes

Moreover, lactate-induced histone lactylation drives macrophages toward a reparative phenotype characterized by reduced pro-inflammatory cytokine expression, thereby potentially constraining excessive inflammation (107,108)