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However, three (30%) had to stop the treatment after 4 weeks because of local atrophy and telangiectasia [57]

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We also observed an increase in the 18 kDa translocator protein TSPO, which is a mitochondrial cholesterol-binding protein and upregulated in microglia during inflammatory activation associated with neurodegeneration (Fig
In addition, the ratios of some ions (e.g., sodium and chloride) may be important for maintaining plasma, nuclear, and mitochondrial membrane integrity

For example, glucose concentrations in healthy adults are typically 3.2-9.2 mM in ISF, whereas patients with diabetes exhibit a broader range of 1.99-22.2 mM [6]
