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doi: 10.1155/2012/132146

These preclinical insights are bolstered by clinical evidence underscoring the therapy benefits

Moreover, it was found that cyanobacterial CrtW enzymes generally retain much lower activity for such a substrate, compared with Paracoccus and Brevundimonas CrtW proteins [195]

Inflammatory cytokines have also been reported to reduce the availability of tetrahydrobiopterin (BH4), an essential enzyme co-factor in the production of all monoamines that is extremely vulnerable to oxidative stress, by producing reactive oxygen and nitrogen species (Tong et al., 2020)

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