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Description
they also accelerate the breakdown of existing collagen through the activation of enzymes called matrix metalloproteinases (MMPs)
G.TchekalarovaJ
GPD2 deficiency has been shown to lead to a reduction of the nucleocytoplasmic [NAD + ]/[NADH] that decreased the expression of mitochondrial SIRT5 desuccinylase, which increased mitochondrial protein lysine succinylation and decreased the activity of the mitochondrial fatty acid beta-oxidation pathway (Qu et al., 2024)
Nutrients 12(6)
On the other hand, cancer cells sometimes exploit a reversible inactivation of GAPDH via oxidative modification of its active-site cysteine (a GAPDH redox switch), which diverts glucose flux into the pentose phosphate pathway to generate NADPH for antioxidant defense 114
