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Within this context, NGF/TrkA promotes matrix remodeling, monocyte ingress, and macrophage polarization, while BDNF/TrkB modulates dendritic-cell maturation, supports survival and angiogenesis, and may condition T-cell primingtogether positioning neurotrophins as coordinators of tumor persistence and immune exclusion

In some cases, this may affect how well certain nutrients, including vitamin B12, are absorbed