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Thus, consensus screening frequencies have not been established, though some recommend initial baseline testing and at subsequent intervals of no more than 12 years

In vitro and in vivo models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expressions of GCLC, GCLM and SLC7A11 were down-regulated, thereby disrupting the metabolism of glutathione