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Owing to the small size of available RCTs and a lack of long-term follow-up data from RCTs, the strength of this recommendation is graded as moderate

10.1007/s00107-020-01637-3 20 BountagkidouO

The failure of NE inhibitors alone (116), and the data for brensocatib in the Phase 2 WILLOW trial (115, 202), suggests that combined inhibition of NSPs, as well as inhibition prior to extracellular release by the neutrophils, may be required for observation of efficacy in bronchiectasis

doi: 10.1001/archgenpsychiatry.2010.110

Vit-D deficiency is also associated with an increase in thrombotic episodes, frequently reported in COVID-19 695