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These results suggested that L-theanine may regulate cytokine secretion in rat splenic lymphocytes by activating the expression of Rap1A and HMGCR proteins involved in the mevalonate biosynthesis pathway [62]

Conversely, ferroptosis-related release of oxidized byproducts and iron ions feeds back to escalate inflammation and further damage cartilage and synovium, establishing a vicious cycle

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