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In APP/PS1 mice, subcutaneous injection of 27-OHC increased gene and protein expression of APP, BACE1, and receptor for advanced glycation end products (RAGE), while decreasing expression of a disintegrin and metalloprotease 10, LRP1, and insulin-degrading enzyme (IDE) (Zhang et al., 2019)

However, prolonged or intense physical activity can deplete intracellular GSH levels because GSH is oxidized to its disulfide form, glutathione disulfide (GSSG), during ROS detoxification [69,70]

The timeline for sphincter improvement in animal studies varies based on administration route and severity of dysfunction

Sarcosine has numerous function in humans including regulation of glycine transport, protein synthesis, and DNA methylation

Role: Co-Investigator