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The blood glutamine concentration can fall by up to 3050 % under catabolic conditions, while at the same time, skeletal muscle glutamine concentration may fall by up to 50 % (Reference Smedberg, Rooyackers and Norberg5,Reference Cruzat, Pantaleao and Donato7,Reference Cruzat, Bittencourt and Scomazzon9)

Lactate production The biological functions of lactate in the TME have transcended traditional metabolic understanding, revealing its characteristics as a multifunctional signaling molecule

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Discussion Despite the importance of this topic in clinical practice, an adequate substitute for Risperidone with a more favorable side effect profile has not been found

Di Martino V, Verhoeven DW, Verhoeven F, Aubin F, Avouac J, Vuitton L, Liot F, Thvenot T, Wendling D (2022) Busting the myth of methotrexate chronic hepatotoxicity