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Moreover, since recent studies have shown that the de- and remyelination extend as well the cellular composition seems to differ between white and gray matter MS lesions (Bo et al., 2007) the cuprizone model becomes increasingly attractive to study the underlying pathophysiological mechanisms of de- and remyelination to uncover regional differences (Gudi et al., 2009

Weaker circadian signals mean fragmented sleep, difficulty falling asleep, reduced slow-wave sleep, and impaired REM cycles
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