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Superoxide anions are potent reactive oxygen species (ROS) that can cause significant damage to cellular components, including DNA, proteins, and lipids, if not properly scavenged

While their mechanisms appear to operate through different biological systems, both peptides provide valuable insight into how cells coordinate complex repair processes

N Engl J Med (1994) 331:132530

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Although it is unknown if the ion transport activity of NCC is required to interact with IL-18 (Wang et al., 2015), the potential functional/molecular interplay between NCC and GLP-1 receptors implies a permissive role for the former in the prandial islet secretory response to incretins
