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Although CGI-58 appears to play a role in lipolysis, more studies are needed to elucidate the molecular mechanism of its activation of ATGL as well as its physiological role in living organisms

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Stockli J, Zadoorian A, Cooke KC, Deshpande V, Yau B, Herrmann G, et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 35

Sirtuins also perform other post-translational reactions such as NAD + -dependent desuccinylation, diacylation, and demalonylation, and are important in regulating metabolism, allowing metabolic plasticity 7