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Studies comparing combination therapy to individual peptides show enhanced reduction of inflammatory markers and improved preservation of tissue function, particularly in chronic inflammatory conditions where both protection and repair are needed simultaneously

MRI-assessed injury volume gives researchers an imaging-based marker

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The synergy between exogenous MOTS-c and exercise is not merely additive: because MOTS-c mimics one of the molecular consequences of high-intensity exercise (AMPK activation via AICAR accumulation), concurrent exercise training may amplify the peptide's effects on GLUT4 translocation and mitochondrial biogenesis