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Excessive ROS not only damages sperm function but also disrupts the gut microbiome, exacerbating systemic inflammation and oxidative imbalance [238]

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For example, modulation of p21, p27, cyclins D1/E, and CDKs 2/4 contributes to checkpoint arrest and facilitates apoptotic signaling ( 4.3 Anti-inflammatory mechanisms Chronic inflammation is an established driver of tumorigenesis, promoting malignant transformation, angiogenesis, immune evasion, and extracellular matrix remodeling (96)

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IgA-mediated human autoimmune hemolytic anemia as a result of hemagglutination in the spleen, but independent of complement activation and FcRI