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8-Isoprostane: A lipid peroxidation product in gingival crevicular fluid in healthy, gingivitis and chronic periodontitis subjects

doi: 10.1158/2326-6066.CIR-21-0778 109 HoodJLSan RomanSWicklineSA

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The hydrophilic GSH-conjugate (R-SG) formed intracellularly is excreted from the cell by the multidrug resistance-associated protein MRP and then processed subsequently by gamma-glutamyltransferases, dipeptidases and N-acetyltransferases to an N-acetylcysteine conjugate, also known as mercapturic acid, which will be excreted in the kidney to urine [35]