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A 2010 meta-analysis [20] of major randomized placebo-controlled trials (98,886 subjects in total, Table 1) investigating the effects of the antioxidant supplement on prevention of diabetes or effect on glucose homeostasis showed no effect from vitamin E, vitamin C, beta-carotene, selenium, zinc, and combinations of these

The novel mechanism by which 4-HNE inhibits NLRP3 is through its ability to directly bind to the critical domains of NLRP3, disrupting its interaction with the adapter protein NEK7, a key step in inflammasome activation, thereby preventing caspase-1 activation

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Because only qualitative analysis was performed, the exact doses of illicit PCT drugs were unknown