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The hydroxylation of cholecalciferol in the liver is catalyzed by cytochrome P450 vitamin D 25-hydroxylases (for example CYP2R1, CYP2D11 and CYP2D25) yielding calcifediol [136, 137]
This degradation releases NF-B from the IB complex, facilitating its translocation to the nucleus, where it binds to the promoter region of target genes, including Il-6 , to activate their transcription 29
Extracellular TF - bound iron interacts with TFR1 membrane protein for cell iron uptake, while ferritin is a protein that stores iron inside cells, and decreased expression of ferritin releases free iron, leading to ferroptosis 40
The epidural space is normally filled with fat and blood vessels
