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Glutamate (Glu) is an important excitatory amino acid neurotransmitter, with the highest content in brain tissue, released by about 3% of synapses, and acts on postsynaptic membrane receptors, mainly the N-methyl-D-aspartate receptor subtype (NMDAR), to exert excitatory regulatory effects

Moreover, zinc supplementation has been shown to reduce the vulnerability of tumor cells to TNF-dependent lysis mediated by CD8 + T cells, whereas zinc chelation enhances this susceptibility