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Description
This seemingly small chemical modification drastically alters its pharmacokinetics, making the molecule highly lipophilic (fat-soluble)

Hershman randomized women receiving adjuvant taxane chemotherapy for early breast cancer evenly to either oral ALC 1,000 mg three times daily or matching placebo, for 24 weeks

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10.1097/00002093-199809000-00001 [DOI] [PubMed] [Google Scholar] Mueckler M
