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Oral administration of thymoquinone mitigates the effect of cisplatin on brush border membrane enzymes, energy metabolism and antioxidant system in rat intestine

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The history of pharmacology is full of molecules with excellent rodent data that failed in human trials

Chandel, NS 49 ) (2357), wherein low doses of stimulation and high doses of inhibition are observed, and the term to describe this phenomenon is hormesis. This article illustrates the redox biology and oxidative stress caused by ROS and the potential to alleviate disease without interfering with healthy tissue 49

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