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Further experiments on SD rats involved leg injection of 2.5 mg/mL dexamethasone to construct an osteoporosis rat model, with shikonin administered via leg injection for intervention

10.1074/jbc.M312693200 [DOI] [PubMed] [Google Scholar] Cochen De Cock V, Girardot-Tinant N, Woimant F, & Poujois A (2018)

Radial stem astrocytes (aka neural stem cells): Identity, development, physio-pathology, and therapeutic potential

About 510% of ALS cases are familial [180], which is linked to mutations in more than 30 genes, including Superoxide dismutase 1 (SOD1), Chromosome 9 Open Reading Frame 72 (C9orf72), and TAR DNA-binding protein (TARDBP) [181]

Mapping disease-related mutations of SRD5A2 to our structure also provides feasible molecular mechanisms for the effects of those mutations in 5-reductase deficiency