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The group of Von Zastrow was the first to identify a protein, named GASP for GPCR associated sorting protein, which could actively target DOR to lysosome (Whistler et al., 2002)

In addition to inhibiting osteoclast function and inducing osteoclast apoptosis, some studies have also shown that bisphosphonates have effects on osteoblast and osteocyte function

References to biological activity on this page are provided for research context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit

Treatment frequency depends on individual goals but is typically weekly or bi-weekly

10.1161/01.ATV.0000056744.26901.BA 72 LetunicI.PeerB