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In vitro assays using BaF-BO3 cells transfected with the hGH receptor confirmed that AOD9604 does not compete for the hGH receptor and does not induce cell proliferation unlike intact hGH establishing that it operates via a novel mechanism distinct from traditional hGH-stimulated pathways
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Second, they raise the possibility of interindividual variations in N-terminal cleavage or differences across organs or cell types or in diseased tissues that modulate receptor signaling
Physiological Rep
