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TB-500 acts as a potent endothelial cell chemoattractant, stimulating 4-6-fold increases in HUVEC migration[4]

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Regarding cellular markers of inflammation, some studies found that the ex-vivo LPS-stimulated production of TNF- 232,233 , IL-1, and IL-6 203,232234 by human monocytes increased during sleep deprivation but decreased during regular nocturnal sleep 54,203,232234

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