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Clinical trials showed modest fat loss of roughly 2-3 kg over 12 weeks, and the compound was never approved as a pharmaceutical because efficacy did not meet the threshold for drug registration (Heffernan et al., 2001)

Cardiovascular outcomes with tirzepatide versus dulaglutide in type 2 diabetes

Expected timeline: Similar pattern to topical-only but potentially accelerated and more pronounced results due to enhanced absorption

However, pretreatment with 10 M GHK-Cu significantly reduced the secretion of both TNF- and IL-6 to much lower levels, confirming its anti-inflammatory properties

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