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Darmishonnejad Z, et al
The mechanism is that polydatin can ameliorate oxidative stress and apoptosis injury by activating the NRF2/HO-1 signaling pathway (Li et al., 2022a)

Nevertheless, there are barriers and disadvantages in putting the KD into practice, such as palatability issues, compliance issues, side effects (usually mild), variable response rates, and restrictions to the daily life of the patient (15)

When two patients were taken off NAC for a period of 2 weeks, rapid deterioration in their conditions ensued including a return of copious drooling in the youngest patient (Eylar et al
