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A later study [46] investigated the effects of CBG on Huntingtons disease pathology in a 3-nitropropionate-induced model in mice

It has been confirmed as a novel metabolite of Hcy, which is generated by the conversion of Hcy to Hcy-thiolactone catalyzed by methionyl-tRNA synthetase 15

Furthermore, curcumin can pass through the BBB, potentially treating NDs linked to inflammation, OS, and apoptosis

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Furthermore, signal transducer and activator of transcription 3 (STAT3) can inhibit the mTOR/HIF-1 pathway by activating AMP-activated protein kinase (AMPK), leading to reduced cell proliferation and increased apoptosis (38)