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Some start weekly for a short period, then move to every two to four weeks

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The search for novel pharmacological targets is moving beyond traditional neurotransmitter systems to address the underlying neuroimmune and molecular pathology, with significant research into drugs that inhibit the activation of spinal and brain microglia, such as smallmolecule antagonists of the purinergic P27 receptor or p38MAPK inhibitors, which in preclinical models of widespread pain can attenuate the release of proinflammatory cytokines (e.g., IL1, TNF) and reduce painlike behaviors [421]

Anti-Cancer Agents Med Chem 21(4):433444