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Nature 555 , 210215 (2018)

Research has indicated that dietary choices, particularly high-fat diets, significantly influence the gut microbiota, exacerbating DED symptoms through mechanisms such as decreased tear secretion, increased oxidative stress, and heightened apoptosis (Wu et al., 2020)

This involvement points to mechanisms such as oxidative stress, apoptosis, and sustained inflammation, which are central to the progression of the disease

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Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX- and MDM2-mediated inhibition of WT p53 in patients with solid tumors and lymphomas