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As a powerful Nrf2 agonist found in cruciferous vegetables (130), Nrf2 activation induced by sulforaphane treatment not only upregulates its downstream target genes, including xCT, GPX4 and multiple Atgs, but also disrupts the formation of Beclin1-xCT complex by promoting autophagy

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DADS were identified to have diminished inflammation, oxidative stress and DNA lesions on the bladder over the topics of pro-inflammation cytokines regulation and also the MAPKs signaling pathways (Nanjwade et al., 2015)

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