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All these can impair insulin responsiveness and blunt critical nodes within the insulin signaling cascades, such as INSR/Insulin receptor substrate (IRS) and phosphoinositide 3-kinase (PI3K)/Akt nodes [8]
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Despite extensive pre-clinical investigations into alternative toxin-targeting therapeutic strategies, only bezlotoxumab and actoxumab have progressed to clinical trials, emphasizing the need for further treatment research
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