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Acknowledgements This research was supported by the South Carolina Clinical & Translational Research Institute, with an academic home at the Medical University of South Carolina, CTSA NIH/NCATS grant numbers UL1TR001450 and UL1TR000062, NIH F31NS108623, and NIDA DA003906

Possible Side Effects 5-Amino-1MQ has been explored in laboratory and experimental research settings, and observations in some research contexts have included: Injection-site irritation or discomfort Temporary redness or swelling Headaches Nausea Fatigue or temporary energy-related variability Restlessness or stimulation-related observations Appetite-related changes Gastrointestinal discomfort Responses and tolerability observations may vary depending on: Experimental conditions Dosage ranges Protocol duration Administration frequency Concurrent compounds Individual sensitivity Higher-frequency or higher-range experimental protocols may increase the likelihood of tolerability-related observations in some research models

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