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PQQ protected against the decline of mitochondrial respiratory capacity in the oxidative stress-induced premature senescence of HEI-OC1 cells In order to confirm the protective effect of PQQ pretreatment in mitochondrial biogenesis and metabolic function in HEI-OC1 cells, we evaluated the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR) using a XF24 extracellular flux analyzer, which measures the fundamental parameters of the electron transport chain (ETC), basal OCR, ATP-linked respiration, maximal OCR, spare respiratory capacity and proton leak (Fig

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Acetylcarnitine reduces the immobility of rats in a despair test (constrained swim)