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Keywords: GHK, TGF-1, pulmonary fibrosis, epithelial-to-mesenchymal transition, Smad, collagen Introduction Idiopathic pulmonary fibrosis (IPF) is a severe respiratory disease characterized by progressive and diffuse pulmonary fibrosis and restrictive ventilation dysfunction that eventually leads to respiratory failure

PDX models have been successfully established from all major molecular MB subgroups and have demonstrated stability across multiple passages, although subclonal populations may undergo selection during serial transplantation