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Pellagra can be prevented by about 11 mg NE/day, but 12 mg to 16 mg NE/day has been found to normalize the urinary excretion of niacin metabolites (breakdown products) in healthy young adults

Su B, Wang X, Lee HG, Tabaton M, Perry G, Smith MA, Zhu X

10.1039/d4nr02039a [DOI] [PubMed] [Google Scholar] Yallapu M

For older adults, typical doses of iron repletion of 50 to 60 mg can be challenging due to side effects such as constipation, diarrhea, and abdominal cramping

This competitive interaction has important therapeutic implications, as Fe supplementation is used to treat Mn-related metabolic disorders, possibly by reducing oxidative damage 115