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It is posited by researchers that increased cAMP levels may activate protein kinase A (PKA), which is hypothesized to be an important intracellular signaling molecule

[DOI] [PMC free article] [PubMed] [Google Scholar] Barhoi D

Genes Cells (2025) 30

It can also be promoted by overexpression of MFN to enhance ATP production and reduce ROS generation in the heart
