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A significant inhibition of the enzymatic activity has also been observed with the antihypertensive drug verapamil and the histamine H2 receptor antagonist cimetidine, although the clinical use of the latter is currently anecdotal [23,80]

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[53] evaluated the therapeutic efficacy of APTATstat3-9R, a high-affinity peptide conjugate that inhibits signal transducer and activator of transcription 3 (STAT3) phosphorylation via cell-penetrating 9-arginine motif modifications, a STAT3 phosphorylated cell-permeable peptide inhibitor, for the indication of improving PF